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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions Avapro (irbesartan) 300 mg Prices, Discount Comparisons & Savings Options Avapro (irbesartan) 300 mg discount prices range from per pill or unit. Irbesartan blocks the hormone angiotensin thereby relaxing blood vessels, causing them to widen Initial dose: 150 mg orally once a day with or without food. 300 MG. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Product Description: Take Avapro exactly as prescribed by your doctor. This drug also slows down the progression of kidney disease in diabetic patients. HYDROCHLOROTHIAZIDE; IRBESARTAN is a combination of a drug that is a diuetic and one that relaxes blood vessels. To treat hypertension the recommended starting dose of Avapro is 150 mg once daily. 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